Comprehensive preanalytics solution for spatial biology
Spatial Station™ is a compact, one-stop solution that automates the most labor-intensive steps of spatial biology sample preparation — delivering reproducible results, minimizing reagent waste, and freeing your time for breakthrough discoveries.
- Panel design
- Panel mixing
- Dewax & HIER
- Staining
- Ready for imaging
Purpose-built for Spatial Biology
Uniform and Gentle Automated Staining
- Stain up to 12 slides at once
- 100 μL staining volume per sample with capillary cap and laminar flow
- 0–100 °C temperature control with thermal module
Pushbutton Panel Mixing
- Develop large antibody panels and cocktails while managing and storing your reagent inventory
- Eliminates the need for individual tube handling, uncapping, and recapping
- Precision tracking of remaining reagent levels
- 1 µL
- minimum mixing volume at 5% CV
- 5 µL
- minimum dead volume from a standard 0.5 mL antibody vial
Touchscreen UI and Protocol Editing
- Effortlessly create and customize protocols
- Supports 21 CFR Part 11 compliance with user account log in and run logs
- Infinite program flexibility
State-of-the-Art Liquid Handling and Detection Monitoring
- Capacitive liquid level detection powered by Hamilton technology with black conductive CO-RE tips
- Warns you when reagents are missing or volumes are insufficient for assay completion
- 5 µL minimum dead volume from a standard 0.5 mL antibody vial
Spatial Station™ Demo Video
Workflows
Assays it automates
One instrument, validated across histology, proteomics and transcriptomics assays.
Histology
Multiplexed Proteomics
Spatial Transcriptomics
Reagent Cocktailing
Dewax
High-content analysis methods require dewaxing of formalin-fixed paraffin-embedded (FFPE) specimens prior to staining. Manual dewaxing is labor-intensive and inserts variability between operators and labs. The Spatial Station™ ensures complete and consistent dewaxing without using harsh xylenes.
Antigen Retrieval
Epitope retrieval through heating in a buffered solution (HIER) is critical for spatial biology. Precise heating (0-100 C) and humidity control combined with automation take the guesswork out of HIER and enable hands-free protocol optimization.
H&E
Hematoxylin and Eosin stain is the gold standard in medical diagnosis and pathology. The Spatial Station™ quickly and reproducibly automates the H&E stain workflow, combining morphology with any spatial biology analysis on any tissue.
IHC
From dewaxing and epitope retrieval through staining, the entire IHC sample preparation procedure can be automated on the Spatial Station™. Use your own buffers and antibodies for reproducible, high-quality, hands-free IHC staining.
Opal/PSP
Multiplexed Immunofluorescence techniques like Opal enable highly plexed analysis of the tumor microenvironment. Automate the entire workflow and achieve optimal results with walkaway efficiency and consistent control.
PCF/CODEX
PhenoCycler technology detects 100+ targets at single-cell resolution. The Spatial Station™ automates the entire pre-imaging workflow with robust fixation for consistent and vigorous sample staining.
IMC
Automating the IMC sample prep protocol makes the hydrophobic barrier pen a tool of the past. Capillary gap methodology ensures uniform staining while consuming up to 5X less reagent with no risk of leakage.
GeoMx
The Spatial Station™ automates the entire GeoMx pre-imaging workflow, including dewaxing+HIER, overnight staining at 4 C, and post-imaging H&E staining with 50-70% reduced reagent usage.
RNAScope
RNAScope in situ hybridization allows for spatial genomics at single-molecule resolution. Automate pretreatment steps to ensure consistent probe hybridization across samples.
10x Visium
Visium is a popular spatial transcriptomics platform from 10x Genomics offering comprehensive coverage of the transcriptome with near-single cell resolution. The Spatial Station™ automates the entire 2-day Visium FFPE CytAssist prep protocol, including dewaxing, H&E staining, and post-ligation washes before CytAssist transfer, doubling throughput to up to 4 slides per batch with less than 1 hour of hands-on time.
Panel Mixing
Automated panel mixing, reporter plate pipetting, and antibody cocktail preparation using an intuitive design platform that integrates with universal storage modules for reproducible, hands-free panel design.
Modules and capabilities
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Uniform Capillary Gap Staining
Reduce reagent usage and artifacts while improving signal-to-noise
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0-100 °C Precision Temperature Control
Achieve baking, HIER, and overnight incubations reproducibly
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Panel Mixing
Build complex antibody panels hands-free while managing your inventory
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Bring Your Own Chemistries
Use our simple kits in combination with your own reagents: instrument is agnostic
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Touchscreen Protocol Builder
Create, select, edit, and customize protocols and view run reports from an intuitive interface
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Plug-n-play Applications & Kits
Automate routine assays with turnkey verified protocols and single-use Skylab™ kits
Tech specs
| Dimensions | 24 x 22 x 24 in |
|---|---|
| Weight | 85 lbs |
| Heating / Cooling | Yes / Yes |
| Sample Throughput | 12 samples (ST), 32 samples (HT) |
| Programming Flexibility | Infinite |
| Panel Mixing | Yes |
| Staining Volume | 100 uL (slides) and 60 uL (coverslips) |
| Dead Volume | 5 µL (from a standard 0.5 mL antibody vial) |
| Minimum Mixing Volume | 1 µL at 5% CV |
| Precision pipetting | Automated liquid handling surpasses manual pipetting accuracy and reproducibility |
| Certifications | CE, UL, FCC, ISO 13485, 21 CFR Pt11 |